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    Both dosimetric methods showed a steep dose-distance fall-off relationship (proportional to the reciprocal of the cube of the distance from the probe tip). An e-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that per mediates circadian transcription through other sequences in this fragment. We have used epidural scs for pain control during the past 15 years.

    All 12 patients experienced relief of pain after trial stimulation and had their systems permanently implanted. The animals were killed at varying intervals of time, and histological examinations were performed. The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length.

    The dosimetry was characterized by two independent methods thermoluminescent dosimeters and radiochromic film. Rats and dogs that were killed weeks to months after liver irradiation tended to have sharply demarcated lesions. The purpose of this study was to determine the efficacy of spinal cord stimulation (scs) in patients with symptoms of reflex sympathetic dystrophy (rsd), a disabling clinical condition with significant consequences of morbidity and loss of productivity.

    At an average of 41 months follow-up, all patients were using their stimulators regularly and only two were receiving adjunctive minor pain medication. The level of pain present pre- and postoperatively was determined by administering a modified mcgill pain questionnaire and a visual analog scale to each patient. Furthermore, possible correlations between white matter lesion scores, ventricular width, and age were investigated.

    These results indicate that v-src, but not c-src527, can bypass the requirement for a functional igf-i receptor in the full transformation of mouse embryo fibroblasts and suggest that qualitative and quantitative differences between the two oncogenes can be used to identify some of the signals relevant to the mechanism(s) of transformation. Phosphorylation of the e2f-1-dp-1 heterodimer by cyclin b-dependent kinases, however, did not result in down-regulation of its dna-binding activity, as is readily seen after phosphorylation by cyclin a-dependent kinases, suggesting that phosphorylation per se is not sufficient to regulate e2f dna-binding activity. Scs is an effective treatment for the pain of rsd, including recurrent pain after ablative sympathectomy.

    Thus, the activities of e2f, a family of transcription factors involved in cell proliferation, are regulated by at least two types of cell growth regulators the retinoblastoma protein family and the cyclin-dependent kinase family. Heat transfer from the probe to dog brain was studied in vivo by placing thermocouple sensors around the probe tip before irradiating. The purpose of the present study was to investigate whether meningeal fibrosis causes increased resistance to cerebrospinal fluid outflow (r(out)) andor increased b-wave activity and whether pathological changes in the brain parenchyma after brain compliance, causing increased b-wave activity. We previously showed in vivo that coding-end processing is specific for each coding end, suggesting that specific motifs in a coding-end sequence influence nucleotide deletion and p-region formation. Eight patients reported excellent pain relief, and four patients described good results.


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    We have used epidural scs for pain control during the past 15 years. At an average of 41 months follow-up, all patients were using their stimulators regularly and only two were receiving adjunctive minor pain medication. Scs is an effective treatment for the pain of rsd, including recurrent pain after ablative sympathectomy. The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length. Normal-pressure hydrocephalus (nph) is a potentially treatable syndrome with abnormal cerebrospinal fluid dynamics.

    Eight of the 12 patients had undergone previous ablative sympathectomy. The dosimetry was characterized by two independent methods thermoluminescent dosimeters and radiochromic film. The animals were killed at varying intervals of time, and histological examinations were performed. These findings indicate that the sequences of the coding ends determine their own processing and have a profound impact on the development of the primary b- and t-cell repertoires. The study involved a group of 38 consecutively studied patients with clinical and radiological evidence of idiopathic nph, for whom a frontal brain biopsy was obtained.

    C, thereby excluding hyperthermia as a significant contributor to the formation of lesions. R- cells, a line of mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor i (igf-i) receptor genes, are refractory to transformation by several viral and cellular oncogenes. We propose that each coding-end sequence dictates a unique hairpin structure, the result of a particular energy conformation between nucleotides organizing the loop and the stem, and that the interplay between this structure and specific sequence motifs influences the frequency and location of nicks which open the coding-end hairpin. Although v-src is a more potent inducer of tyrosine phosphorylation than c-src527, the extent of phosphorylation of either insulin receptor substrate 1 or shc, two of the major substrates of the igf-i receptor, does not seem sufficiently different to explain the qualitative difference in soft agar growth. . This enhancer drives high-amplitude mrna cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (per) dependent. An e-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that per mediates circadian transcription through other sequences in this fragment. These results indicate that v-src, but not c-src527, can bypass the requirement for a functional igf-i receptor in the full transformation of mouse embryo fibroblasts and suggest that qualitative and quantitative differences between the two oncogenes can be used to identify some of the signals relevant to the mechanism(s) of transformation. In this study, we created a panel of recombination substrates containing actual immunoglobulin and t-cell receptor coding-end sequences and dissected the role of each motif by comparing its processing pattern with those of variants containing minimal nucleotide changes from the original sequence. Detailed mutagenesis of this region indicated that transactivation is mediated by three highly conserved sequences, spanning amino acids 13 to 22 (subdomain a), 32 to 38 (subdomain b), and 60 to 73 (subdomain c).

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